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nccs npc processed somatic wes data  (Mendeley Ltd)

 
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    Mendeley Ltd nccs npc processed somatic wes data
    Clinical characteristics and germline variants associated with <t>NPC</t> subtypes ( n = 303 [L], 201 [A], 246 [D], and 244 [AD]) (A) Representative MRI scans of each NPC subtype (red, bulky tumor; blue, small tumor). (B) CONSORT diagram of patient selection for the <t>NCCS</t> cohort. (C) Association of NPC subtypes with OS and DFS. (D) Manhattan plot showing p values of germline variants associated with L, A, D, or AD subtype relative to healthy controls. Points above dashed line ( p = 8.9 × 10 −7 ) are significant variants post-Bonferroni adjustment. (E) Variants significantly associated with NPC subtypes identified in both the comparison against healthy controls and the comparison against all controls. (F and G) Tumor expression of FADS1 and DFS in A-subtype patients with CC vs. TC genotype of rs72643557 , respectively. The boxplots represent the IQR, with the horizontal line indicating the median. Mann-Whitney U test and log-rank test was used to compare between CC vs. TC in (F) and (G), respectively. Abbreviations: NPC, nasopharyngeal carcinoma; CONSORT, Consolidated Standards of Reporting Trials; QC, quality control; OS, overall survival; DFS, disease-free survival; L, limited; A, ascending; D, descending; AD, ascending-descending.
    Nccs Npc Processed Somatic Wes Data, supplied by Mendeley Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/nccs npc processed somatic wes data/product/Mendeley Ltd
    Average 90 stars, based on 1 article reviews
    nccs npc processed somatic wes data - by Bioz Stars, 2026-06
    90/100 stars

    Images

    1) Product Images from "Tumor immune microenvironment delineates progression trajectories of distinct nasopharyngeal carcinoma phenotypes"

    Article Title: Tumor immune microenvironment delineates progression trajectories of distinct nasopharyngeal carcinoma phenotypes

    Journal: Cell Reports Medicine

    doi: 10.1016/j.xcrm.2025.102143

    Clinical characteristics and germline variants associated with NPC subtypes ( n = 303 [L], 201 [A], 246 [D], and 244 [AD]) (A) Representative MRI scans of each NPC subtype (red, bulky tumor; blue, small tumor). (B) CONSORT diagram of patient selection for the NCCS cohort. (C) Association of NPC subtypes with OS and DFS. (D) Manhattan plot showing p values of germline variants associated with L, A, D, or AD subtype relative to healthy controls. Points above dashed line ( p = 8.9 × 10 −7 ) are significant variants post-Bonferroni adjustment. (E) Variants significantly associated with NPC subtypes identified in both the comparison against healthy controls and the comparison against all controls. (F and G) Tumor expression of FADS1 and DFS in A-subtype patients with CC vs. TC genotype of rs72643557 , respectively. The boxplots represent the IQR, with the horizontal line indicating the median. Mann-Whitney U test and log-rank test was used to compare between CC vs. TC in (F) and (G), respectively. Abbreviations: NPC, nasopharyngeal carcinoma; CONSORT, Consolidated Standards of Reporting Trials; QC, quality control; OS, overall survival; DFS, disease-free survival; L, limited; A, ascending; D, descending; AD, ascending-descending.
    Figure Legend Snippet: Clinical characteristics and germline variants associated with NPC subtypes ( n = 303 [L], 201 [A], 246 [D], and 244 [AD]) (A) Representative MRI scans of each NPC subtype (red, bulky tumor; blue, small tumor). (B) CONSORT diagram of patient selection for the NCCS cohort. (C) Association of NPC subtypes with OS and DFS. (D) Manhattan plot showing p values of germline variants associated with L, A, D, or AD subtype relative to healthy controls. Points above dashed line ( p = 8.9 × 10 −7 ) are significant variants post-Bonferroni adjustment. (E) Variants significantly associated with NPC subtypes identified in both the comparison against healthy controls and the comparison against all controls. (F and G) Tumor expression of FADS1 and DFS in A-subtype patients with CC vs. TC genotype of rs72643557 , respectively. The boxplots represent the IQR, with the horizontal line indicating the median. Mann-Whitney U test and log-rank test was used to compare between CC vs. TC in (F) and (G), respectively. Abbreviations: NPC, nasopharyngeal carcinoma; CONSORT, Consolidated Standards of Reporting Trials; QC, quality control; OS, overall survival; DFS, disease-free survival; L, limited; A, ascending; D, descending; AD, ascending-descending.

    Techniques Used: Selection, Comparison, Expressing, MANN-WHITNEY, Control

    Analysis of TIME in NPC subtypes using whole slide imaging ( n = 39 [L], 35 [A], 33 [D], and 48 [AD]) (A) Workflow of spatial analyses leading to immune classification based on spatial distribution and density of immune-rich tiles within the WSI of the tumor. (B) Proportion of immune-rich tiles in WSIs for the four subtypes. (C) Mean tumor-immune tile distances in WSIs for the four subtypes. (D) Distribution of the three immune classes in WSIs for the four subtypes. (E) Association of immune classes with DFS for both NCCS and JXCH cohorts. No hazard ratio was computed for JXCH cohort due to absence of DFS events in the immune-dense class. Log-rank test was used to compare between immune classes. The boxplots represent the IQR, with the horizontal line indicating the median. Mann-Whitney U test was used to compare between NPC subtypes unless otherwise indicated. Abbreviations: WSIs, whole-slide images; DFS, disease-free survival.
    Figure Legend Snippet: Analysis of TIME in NPC subtypes using whole slide imaging ( n = 39 [L], 35 [A], 33 [D], and 48 [AD]) (A) Workflow of spatial analyses leading to immune classification based on spatial distribution and density of immune-rich tiles within the WSI of the tumor. (B) Proportion of immune-rich tiles in WSIs for the four subtypes. (C) Mean tumor-immune tile distances in WSIs for the four subtypes. (D) Distribution of the three immune classes in WSIs for the four subtypes. (E) Association of immune classes with DFS for both NCCS and JXCH cohorts. No hazard ratio was computed for JXCH cohort due to absence of DFS events in the immune-dense class. Log-rank test was used to compare between immune classes. The boxplots represent the IQR, with the horizontal line indicating the median. Mann-Whitney U test was used to compare between NPC subtypes unless otherwise indicated. Abbreviations: WSIs, whole-slide images; DFS, disease-free survival.

    Techniques Used: Imaging, MANN-WHITNEY



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    nccs npc processed somatic wes data  (Mendeley Ltd)
    90
    Mendeley Ltd nccs npc processed somatic wes data
    Clinical characteristics and germline variants associated with <t>NPC</t> subtypes ( n = 303 [L], 201 [A], 246 [D], and 244 [AD]) (A) Representative MRI scans of each NPC subtype (red, bulky tumor; blue, small tumor). (B) CONSORT diagram of patient selection for the <t>NCCS</t> cohort. (C) Association of NPC subtypes with OS and DFS. (D) Manhattan plot showing p values of germline variants associated with L, A, D, or AD subtype relative to healthy controls. Points above dashed line ( p = 8.9 × 10 −7 ) are significant variants post-Bonferroni adjustment. (E) Variants significantly associated with NPC subtypes identified in both the comparison against healthy controls and the comparison against all controls. (F and G) Tumor expression of FADS1 and DFS in A-subtype patients with CC vs. TC genotype of rs72643557 , respectively. The boxplots represent the IQR, with the horizontal line indicating the median. Mann-Whitney U test and log-rank test was used to compare between CC vs. TC in (F) and (G), respectively. Abbreviations: NPC, nasopharyngeal carcinoma; CONSORT, Consolidated Standards of Reporting Trials; QC, quality control; OS, overall survival; DFS, disease-free survival; L, limited; A, ascending; D, descending; AD, ascending-descending.
    Nccs Npc Processed Somatic Wes Data, supplied by Mendeley Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/nccs npc processed somatic wes data/product/Mendeley Ltd
    Average 90 stars, based on 1 article reviews
    nccs npc processed somatic wes data - by Bioz Stars, 2026-06
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    Clinical characteristics and germline variants associated with NPC subtypes ( n = 303 [L], 201 [A], 246 [D], and 244 [AD]) (A) Representative MRI scans of each NPC subtype (red, bulky tumor; blue, small tumor). (B) CONSORT diagram of patient selection for the NCCS cohort. (C) Association of NPC subtypes with OS and DFS. (D) Manhattan plot showing p values of germline variants associated with L, A, D, or AD subtype relative to healthy controls. Points above dashed line ( p = 8.9 × 10 −7 ) are significant variants post-Bonferroni adjustment. (E) Variants significantly associated with NPC subtypes identified in both the comparison against healthy controls and the comparison against all controls. (F and G) Tumor expression of FADS1 and DFS in A-subtype patients with CC vs. TC genotype of rs72643557 , respectively. The boxplots represent the IQR, with the horizontal line indicating the median. Mann-Whitney U test and log-rank test was used to compare between CC vs. TC in (F) and (G), respectively. Abbreviations: NPC, nasopharyngeal carcinoma; CONSORT, Consolidated Standards of Reporting Trials; QC, quality control; OS, overall survival; DFS, disease-free survival; L, limited; A, ascending; D, descending; AD, ascending-descending.

    Journal: Cell Reports Medicine

    Article Title: Tumor immune microenvironment delineates progression trajectories of distinct nasopharyngeal carcinoma phenotypes

    doi: 10.1016/j.xcrm.2025.102143

    Figure Lengend Snippet: Clinical characteristics and germline variants associated with NPC subtypes ( n = 303 [L], 201 [A], 246 [D], and 244 [AD]) (A) Representative MRI scans of each NPC subtype (red, bulky tumor; blue, small tumor). (B) CONSORT diagram of patient selection for the NCCS cohort. (C) Association of NPC subtypes with OS and DFS. (D) Manhattan plot showing p values of germline variants associated with L, A, D, or AD subtype relative to healthy controls. Points above dashed line ( p = 8.9 × 10 −7 ) are significant variants post-Bonferroni adjustment. (E) Variants significantly associated with NPC subtypes identified in both the comparison against healthy controls and the comparison against all controls. (F and G) Tumor expression of FADS1 and DFS in A-subtype patients with CC vs. TC genotype of rs72643557 , respectively. The boxplots represent the IQR, with the horizontal line indicating the median. Mann-Whitney U test and log-rank test was used to compare between CC vs. TC in (F) and (G), respectively. Abbreviations: NPC, nasopharyngeal carcinoma; CONSORT, Consolidated Standards of Reporting Trials; QC, quality control; OS, overall survival; DFS, disease-free survival; L, limited; A, ascending; D, descending; AD, ascending-descending.

    Article Snippet: NCCS NPC processed somatic WES data , This study , Mendeley Data: https://data.mendeley.com/datasets/87cwzd56kh/1.

    Techniques: Selection, Comparison, Expressing, MANN-WHITNEY, Control

    Analysis of TIME in NPC subtypes using whole slide imaging ( n = 39 [L], 35 [A], 33 [D], and 48 [AD]) (A) Workflow of spatial analyses leading to immune classification based on spatial distribution and density of immune-rich tiles within the WSI of the tumor. (B) Proportion of immune-rich tiles in WSIs for the four subtypes. (C) Mean tumor-immune tile distances in WSIs for the four subtypes. (D) Distribution of the three immune classes in WSIs for the four subtypes. (E) Association of immune classes with DFS for both NCCS and JXCH cohorts. No hazard ratio was computed for JXCH cohort due to absence of DFS events in the immune-dense class. Log-rank test was used to compare between immune classes. The boxplots represent the IQR, with the horizontal line indicating the median. Mann-Whitney U test was used to compare between NPC subtypes unless otherwise indicated. Abbreviations: WSIs, whole-slide images; DFS, disease-free survival.

    Journal: Cell Reports Medicine

    Article Title: Tumor immune microenvironment delineates progression trajectories of distinct nasopharyngeal carcinoma phenotypes

    doi: 10.1016/j.xcrm.2025.102143

    Figure Lengend Snippet: Analysis of TIME in NPC subtypes using whole slide imaging ( n = 39 [L], 35 [A], 33 [D], and 48 [AD]) (A) Workflow of spatial analyses leading to immune classification based on spatial distribution and density of immune-rich tiles within the WSI of the tumor. (B) Proportion of immune-rich tiles in WSIs for the four subtypes. (C) Mean tumor-immune tile distances in WSIs for the four subtypes. (D) Distribution of the three immune classes in WSIs for the four subtypes. (E) Association of immune classes with DFS for both NCCS and JXCH cohorts. No hazard ratio was computed for JXCH cohort due to absence of DFS events in the immune-dense class. Log-rank test was used to compare between immune classes. The boxplots represent the IQR, with the horizontal line indicating the median. Mann-Whitney U test was used to compare between NPC subtypes unless otherwise indicated. Abbreviations: WSIs, whole-slide images; DFS, disease-free survival.

    Article Snippet: NCCS NPC processed somatic WES data , This study , Mendeley Data: https://data.mendeley.com/datasets/87cwzd56kh/1.

    Techniques: Imaging, MANN-WHITNEY